Bradley Sturgeon

Main Research Interests:

• Enzymatic generation/detection of radicals (in particular peroxidase enzyme systems) (biochemistry)
• Radical chemistry (organic chemistry)
• Experimental methods to monitor radical chemistry (analytical/physical chemistry): O2 measurements (radical reactions that consume oxygen); UV-vis (monitoring of substrate/product consumption); ESR/EPR spectroscopy (transient radical detection); HPLC (stable product detection)
• Computational methods (physical chemistry)
• Secondary Research Interest
• Brewing Science (mainly the science and history of beer; Recognized BJCP member)
• Electroplating (A Science-Art collaborative project - supported by a Wells Foundation Grant)

B.S. – Illinois State University, 1987

M.S. – Illinois State University, 1989

Ph.D. – University of California Davis, 1994

CHEM 100: Chemistry of the Environment

CHEM 140: General Chemistry

CHEM 140L: General Chemistry Laboratory

CHEM 312: Physical Chemistry I (Thermodynamics)

CHEM 322: Physical Chemistry II (Quantum Mechanics)

CHEM 362: Advanced Physical Chemistry (Computational Chemistry)

INTG 402: Citizenship: Green Initiatives; Water

Publications (partial listing)

Franzen, S.; Sasan, K.; Sturgeon, B. E.; Lyon, B. J.; Battenburg, B. J.; Dumariah, H. G. R.; and Ghiladi, R. Nonphotochemical Base-Catalyzed Hydroxylation of 2,6-Dichloroquinone by H2O2 Occurs by a Radical Mechanism. (2012) J. Phys. Chem. B, 116 (5), 1666–1676.

Sturgeon, B. E.; Battenburg, B. J.; Lyon, B. J.; Franzen, S. Revisiting the Peroxidase Oxidation of 2,4,6-Trihalophenols: ESR Detection of Radical Intermediates. (2011) Chem. Res. Toxicol., 24 (11), 1862–1868.

Connor, H. D.; Sturgeon, B. E.; Mottley, C.; Sipe, H. J. Jr.; Mason, R. P. L-Tryptophan Radical Cation Electron Spin Resonance Studies: Connecting Solution-derived Hyperfine Coupling Constants with Protein Spectral Interpretations. (2008) J. Am. Chem. Soc. 130, 6381-6387.

Sturgeon, B. E.; Chen, Y.-C.; Mason, R. P. Immobilized Enzyme Electron Spin Resonance: A Method for Detecting Enzymatically-Generated Transient Radicals. (2003) Anal. Chem. 75, 5006-5011.

Gunther M. R.; Sturgeon B. E.; Mason R. P. Nitric Oxide Trapping of the Tyrosyl Radical-Chemistry and Biochemistry. (2002) Toxicology 177, 1-9.

Chen, Y.-R.; Deterding, L. J.; Sturgeon, B. E.; Tomer, K. B.; Mason, R. P. Protein Oxidation of Cytochrome c by Reactive Halogen Species Enhances its Peroxidase Property. (2002) J. Biol. Chem. 277, 29781-27991.

Sturgeon, B. E.; Glover, R. E.; Chen, Y.-R.; Mason, R. P. Tyrosine Iminoxyl Radical Formation from Tyrosyl Radical/Nitric Oxide and Nitrosotyrosine. (2001) J. Biol. Chem. 276, 45516-45521.

Gunther, M. R.; Sturgeon, B. E.; Mason, R. P. A Long-Lived Tyrosyl Radical from the Reaction Between Metmyoglobin and Hydrogen Peroxide. (2000) Free Radic. Biol. Med. 28, 709-719.

Chen, Y-R.; Sturgeon, B. E.; Gunther, M. R.; Mason, R. P. ESR Investigation of the Cyanyl Radical in Cyanide/Cytochrome c Oxidase and Azidyl Radical in Azide/Cytochrome c Oxidase/H2O2 Systems. (1999) J. Biol. Chem. 274, 24611-24616.

Sturgeon, B. E.; Sipe, H. J. Jr.; Barr, D. P.; Corbett, J. T.; Martinez, J. G.; Mason, R. P. The Fate of the Oxidizing Tyrosyl Radical in the Presence of Glutathione and Ascorbate: Implication for the Radical Sink Hypothesis. (1998) J. Biol. Chem. 273, 30116-30121.

Sturgeon, B. E.; Burdi, D.; Chen, S. X.; Huynh, B. H.; Edmondson, D. E.; Stubbe, J.; Hoffman, B. M. Reconsideration of X, the Diiron Intermediate Formed During Cofactor Assembly in E. coli Ribonucleotide Reductase. (1996) J. Am. Chem. Soc. 118, 7551-7557.